Where Tolerance Begins and Tone Fades Chronic THC use gradually weakens the body’s endocannabinoid system (ECS) by desensitizing cannabinoid receptors, suppressing natural endocannabinoid tone, and disrupting immune and hormonal balance. The result is tolerance during use and a slow, uneven recovery once cannabis is discontinued. What Does Downregulation Mean? “Downregulation” is biology’s way of describing…